Jinquan Chen
Description
Presents comprehensive insights into triplet excited state dynamics of DNA and RNA across experiment and theory Understanding the excited state dynami
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cs of DNA and RNA is fundamental to addressing both the detrimental and beneficial consequences of UV light on biological systems. While the triplet excited state is a precursor to damaging pathways such as photodamage, mutation, and carcinogenesis, it also offers opportunities for developing targeted therapies through DNA-targeted photosensitizing drugs. Despite its dual role, no single resource has systematically synthesized the experimental and theoretical progress in this field. Excited State Dynamics in DNA and RNA: Experimental and Computational Studies on the Triplet State provides the first comprehensive overview of this rapidly growing interdisciplinary area, bridging photochemistry, photobiology, and photomedicine. Beginning with a historical overview of the field, the volume progresses to cover triplet dynamics in canonical and noncanonical nucleobases, triplet-mediated photochemistry, and drug-sensitized processes in DNA. Later chapters examine cutting-edge computational photobiology and quantum mechanical simulations, highlighting how molecular structure and environment influence excited state behaviors. Offering a holistic perspective on mechanisms underpinning UV-induced damage and therapeutic opportunities, Excited State Dynamics in DNA and RNA: Integrates photochemistry, photobiology, and photomedicine into a unified resource
Presents experimental findings alongside theoretical models
Highlights experimental advances in spectroscopy and ultrafast dynamics
Includes computational studies using ab initio and surface-hopping dynamics simulations
Addresses both canonical and epigenetically modified nucleobases.
Explores implications for drug-sensitized DNA triplet states and photoactivated therapies.
Synthesizes current research trends into a pedagogical framework accessible to non-specialists
Excited State Dynamics in DNA and RNA: Experimental and Computational Studies on the Triplet State is an essential resource for graduate-level and advanced undergraduate courses in molecular biophysics, photochemistry, and chemical biology. It is also a key reference for researchers and professionals working in molecular biology, biophysics, medicinal chemistry, and photomedicine.
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